Mortality Outcome of Controlled Hypertension

Overview

This pooled analysis investigates mortality and severe adverse outcomes in patients with pharmacologically treated and blood pressure-controlled hypertension. Although blood pressure control is the primary goal of hypertension management, some patients continue to experience fatal cardiovascular, cerebrovascular, renal, or unexplained syndromes despite achieving treatment targets. The study aims to identify factors associated with these outcomes and to explore potential contributors beyond blood pressure measurements alone. Literature identification is being conducted using a predefined search strategy based on Medical Subject Headings (MeSH) and relevant free-text keywords related to hypertension, mortality, cardiovascular disease, cerebrovascular disease, renal disease, and associated cardiometabolic conditions. The initial PubMed search yielded 9,298 records. Retrieved studies are undergoing systematic screening and eligibility assessment according to the study protocol. Eligible studies will subsequently undergo full-text review, quality appraisal, and pooled analysis.

Search Yield and Preliminary Evidence Mapping The initial literature search identified 9,298 records relevant to hypertension treatment, blood pressure control, mortality, cardiovascular outcomes, cerebrovascular disease, renal disease, and associated cardiometabolic conditions. Retrieved records were imported into a systematic review management platform for organization, screening, and review management. As of this update, all 9,298 records have undergone initial review. Following title and abstract assessment according to the prespecified protocol, 2,547 records were retained for further evaluation and 6,751 records were excluded from subsequent review stages. Preliminary evidence mapping indicates that the retrieved literature is predominantly concentrated within cardiometabolic and cardiovascular domains. Frequently identified themes include hypertension, antihypertensive treatment, cardiovascular disease, albuminuria, dyslipidemia, comorbid conditions, preeclampsia, and uncontrolled hypertension. These findings are consistent with the intended search strategy and demonstrate broad coverage of clinically relevant factors potentially associated with adverse outcomes among patients receiving hypertension treatment. Studies retained after initial screening continue to undergo eligibility assessment, full-text review, quality appraisal, and data extraction. Quantitative synthesis and pooled analyses will be performed after completion of the review process.