Immunometabolism of Exercise

University of Houston102 enrolled

Overview

This study aims to examine the effects of acute aerobic exercise and cardiorespiratory fitness on cellular metabolism of CD8+ T cells and regulatory T cells (Tregs) found in the peripheral blood of humans. In addition, the study will investigate whether the effects of exercise differ based on exercise intensity, as well as whether the effects of exercise and fitness differ between subpopulations of CD8+ T cells and Tregs. Finally, the study aims to examine whether exercise- and fitness-induced changes in cell metabolism relate to changes in cell function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

102

Conditions

No Condition, Assessment of Healthy Volunteers

Interventions

Acute exercise-moderate intensityBEHAVIORAL

30 minutes of cycling exercise at moderate (90% of first ventilatory threshold)

Acute effects-heavy intensityBEHAVIORAL

Participants will cycle 30 minutes at heavy (110% of first ventilatory threshold) intensity

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women, aged 20-40 years * individuals presenting with average (40th-60th percentile) cardiorespiratory fitness (i.e., VO2max/VO2peak) for their age and sex will be included in acute exercise experiments; individuals with VO2max/VO2peak value \>20ml/kg/min will be included in cardiorespiratory fitness experiments * individuals categorized as 'low risk' for a cardiovascular event/heart disease when screened by American College of Sports Medicine (ACSM) criteria Exclusion Criteria: * adults under the age of 20 and over the age of 40 * Individuals with contraindications to exercise testing will be excluded * Individuals with musculoskeletal impairments preventing them from exercising on a cycle ergometer * Individuals with disease history known to impact the immune system and/or systemic metabolism will be excluded, including autoimmune diseases, HIV, Hepatitis, diabetes, cancer (completed treatment within \<6 months prior), hyper- or hypothyroidism * Pregnancy * Individuals using medications known to impact the cardiopulmonary and/or immune response to exercise with be excluded, including those using medication to control blood pressure (e.g., beta-blockers), daily steroidal and nonsteroidal anti-inflammatories (except daily aspirin), prescription allergy medication, ADHD medication (Ritalin or Adderall), thyroid medication (e.g., Levothyroxine), and chemotherapy (including treatments within the last 6 months). * Individuals habitually using tobacco products within the last 6 months or with excessive alcohol intake (\>10 drinks/week)

Locations (1)

University of Houston

Houston, Texas, United States