Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System

N/ANot Yet RecruitingNCT07193264

Jasmin Rettkowski100 enrolled

Overview

This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake. The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

Healthy Adults; Hematopoietic System; Caffeine

Interventions

Participants receive a single oral dose of 200 mg caffeine under fasting conditions. Blood samples are collected before and three hours after intake to evaluate effects on hematopoietic stem and progenitor cells, including mobilization, function, gene expression, and metabolism.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Able to give consent. * Healthy adults aged ≥ 18 years. * Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months. * Willingness to comply with fasting requirements and study procedures. Exclusion Criteria: * Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome). * Personal history of cancer. * Personal history of hematological disorders. * History of radiation therapy. * Known caffeine hypersensitivity or intolerance. * Known immunosuppression.

Outcomes

Primary Outcomes

Mobilization of hematopoietic stem and progenitor cells

The change in the numbers of mobilized HSPCs (defined as CD34+ cells) \[cells/ml\] in blood (measured by flow cytometry) from baseline to three hours after intake of a single oral dose of 200mg caffeine in habitual caffeine consumers versus non-caffeine consumers.