Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits. Experimental data feature bioactives from Cornelian cherry as potential modulators of vascular function and blood pressure, plausibly via endothelial nitric oxide-related pathways, with possible downstream effects on autonomic reflex control; nevertheless, such links in humans remain poorly explored to date, especially in terms of endurance training and hypoxia tolerance. In this cross-over, placebo-controlled study, a group of healthy amateur long-distance runners underwent two stages of a four-week dietary intervention (separated by four weeks of washout period), receiving Cornelian cherry lyophilisate or placebo. Each supplementation stage was accompanied by the comprehensive evaluation of the cardio-respiratory parameters and endothelial function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
18
Participants receiving a Cornus mas (Cornelian cherry) lyophilisate for 4 weeks.
Participants receiving a starch- and sugar-based placebo for 4 weeks.
Wroclaw Medical University
Wroclaw, Lower Silesian Voivodeship, Poland
Systemic vascular resistance
Resting systemic vascular resistance, evaluated non-invasively with a finger cuff-based device.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
Office blood pressure values (mean, systolic, diastolic)
Resting arterial blood pressure values (mean, systolic, diastolic), measured continuously with a non-invasive, finger cuff-based device.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
Peripheral chemoreflex sensitivity
Peripheral chemoreflex sensitivity, measured with the transient hypoxia test.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
eNOS expression
Endothelial nitric oxide synthase expression, evaluated in the peripheral blood samples.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.