Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

N/AActive Not RecruitingNCT07195370

Isfahan University of Medical Sciences150 enrolled

Overview

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

150

Conditions

Glaucoma Eye Angle Closure Glaucoma

Interventions

This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Eligibility

Sex: ALLMin age: 24 Years

Medical Language ↔ Plain English

Inclusion Criteria:Diagnosis of Primary Angle-Closure Glaucoma. Adults (typically over 40 years old). Ability to provide informed consent. Narrow or closed anterior chamber angle (based on gonioscopy). Intraocular pressure (IOP) controlled with medication but requiring surgery. No previous iridotomy. Exclusion Criteria:econdary glaucoma. Active eye diseases (e.g., infection or inflammation). Advanced cataracts or lens-related issues. Severe visual impairment (e.g., less than 20/200 vision). Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease). Pregnancy or breastfeeding. Previous eye surgery (except for minor procedures). Inability to follow-up with scheduled visits. \-

Outcomes

Primary Outcomes

adverse events

Surgical and postoperative complications (e.g., bleeding, infection, or changes in intraocular pressure).

Time frame: 1 day, 1 week, 1month