Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients

N/ACompletedNCT07195565

Pinar Timur Tasci238 enrolled

Overview

This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.

Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined. In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors. By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.

Study Type

OBSERVATIONAL

Enrollment

238

Conditions

Severe Burns Acute Kidney Injury Critical Illness

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 years and older * Admitted to and treated in the Burn Intensive Care Unit Exclusion Criteria: * Patients with an ICU stay of less than 24 hours * Patients younger than 18 years * Patients with known chronic kidney disease or history of kidney transplantation * Patients admitted with toxic epidermal necrolysis (TEN) * Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission

Locations (1)

Dr. Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

RIFLE criteria classification at CRRT initiation

Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.

Time frame: Baseline( Day0, at CRRT initiation)

Timing of CRRT initiation

Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.

Time frame: Baseline( Day0, at CRRT initiation, recorded from patient medical records)

Survival status of patients

Survival versus non-survival status at the end of hospitalization.

Time frame: At hospital discharge ( end of hospitalization)

Secondary Outcomes

Presence of comorbidities in non-survivors

Documentation of chronic comorbidities (e.g., diabetes, hypertension, cardiovascular disease) in patients who died after CRRT.

Time frame: Baseline( Day0, at hospital admission)

Requirement for mechanical ventilation in non-survivors

Need for invasive mechanical ventilation among non-survivors receiving CRRT.

Time frame: Through ICU stay, up to hospital discharge (or death)

Requirement for inotropic support in non-survivors

Requirement for vasopressor or inotropic agents among non-survivors receiving CRRT.

Time frame: Through ICU stay, up to hospital discharge or death

Hospital length of stay in non-survivors

Data from ClinicalTrials.gov

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