Effects of rTMS on Corticomotor Excitability and Balance Performance in Parkinson's Disease

N/ACompletedNCT07195773

Chung Shan Medical University21 enrolled

Overview

The study investigates the effects of repetitive transcranial magnetic stimulation on motor cortex excitability, balance, and motor function in patients with Parkinson's disease. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on motor cortex excitability.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Parkinson Disease Motor Cortex Excitability Balance Motor Skills Disorders

Interventions

rTMSDEVICE

investigate the effects of repetitive transcranial magnetic stimulation on corticomotor excitability, balance performance, and mobility in patients with Parkinson's disease, and to further explore the effects on corticomotor excitability by single low-frequency and high-frequency repetitive transcranial magnetic stimulation. Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, corticomotor excitability, balance, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with primary Parkinson's disease 2. Age: 40-85 years 3. Hoehn and Yahr scale (H\&Y scale) : I-III 4. Appropriate prescribed medication, and regular intake for more than 2 weeks 5. Can walk more than 10m with or without the use of assistive devices Exclusion Criteria: 1. Any other neurological presentation (Excluding PD) 2. Any neurological surgery that would affect participation in this experiment 3. Orthopedic pathology and Cardiovascular issues 4. MMSE≦24 5. Exercise used for treatment in the last three months 6. Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)

Locations (1)

Chung Shan Medical Unirversity

Taichung, Southern District, Taiwan

Outcomes

Primary Outcomes

Cortical excitability

Transcranial magnetic stimulation

Time frame: Cortical excitability will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

Motor function

UPDRS-III

Time frame: UPDRS-III will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

Secondary Outcomes

Dynamic balance

Functional Reach Test

Time frame: FRT will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

Functional mobility

Timed Up and Go test

Time frame: TUG will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

Data from ClinicalTrials.gov

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