CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α Cascad

N/ACompletedNCT07197151

hui hou32 enrolled

Overview

Collect some tumor tissue specimens from patients who have undergone colorectal cancer surgery and conduct experiments such as immunohistochemistry to observe the expression of related genes in colorectal cancer.

We need to collect postoperative specimens and adjacent normal tissue specimens from patients with colorectal cancer for immunohistochemical staining. There is no need to conduct any other grouping of the patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colorectal Cancer (CRC)Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw

Interventions

Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimensOTHER

Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria:(1) Patients diagnosed with colorectal cancer who received surgical treatment and postoperative chemotherapy (2) Patients who were conscious of their condition and voluntarily participated (3) No other serious underlying diseases Exclusion Criteria:(1) Concurrent other serious chronic diseases or organ damage (2) Diagnosed with benign colorectal tumors

Locations (1)

The Second Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

Outcomes

Primary Outcomes

Immunohistochemical determination of the expression levels of related genes

Time frame: 2022.09-2025.09

Data from ClinicalTrials.gov

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