To analyze the spatiotemporal dynamic evolution of nasopharyngeal carcinoma before and after immunotherapy and during tumor progression, 2\~3 key cell subsets or node molecules were screened to predict the curative effect. Spatial metabolome and organoids were used to elucidate the mechanism of key factors leading to immunotherapy tolerance in NPC and identify new targets for intervention.
Study Type
OBSERVATIONAL
Enrollment
600
This project involves no therapeutic intervention for the subjects.
Failure-free survival (FFS)
Failure-free survival is measured from day of diagnosis until treatment failure, death from any cause, or last follow-up visit, whichever occurred first
Time frame: 3-year
Overall survival (OS)
Overall survival is measured from day of diagnosis until death due to any cause or the latest known date alive
Time frame: 5-year
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