This physiological observational study will assess respiratory drive and inspiratory effort across varying levels of pressure support ventilation (PSV) in adult surgical ICU (SICU) patients after major abdominal surgery. By using non-invasive bedside indices (airway occlusion pressure at 100 ms after the onset of inspiration \[P0.1\], maximum negative occlusion pressure \[Pocc\], and pressure muscle index \[PMI\]), we aim to quantify how patients adapt to changes in ventilatory support and determine patterns of under- and over-assistance. Findings may inform optimal titration of PSV to reduce complications and improve clinical outcomes.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
40
Patients will undergo standardized stepwise PSV changes (baseline, ±3 cmH₂O, ±6 cmH₂O, return to baseline), with 2-minute stabilization and repeated measurements of ventilatory parameters.
Faculty of Medicine, Siriraj Hospital, Mahidol University
Bangkok, Bangkoknoi, Thailand
RECRUITINGRespiratory drive and inspiratory effort across pressure support levels
Respiratory drive and inspiratory effort will be assessed using airway occlusion pressure at 0.1 seconds (P0.1), maximum negative inspiratory occlusion pressure (Pocc), and the pressure muscle index (PMI). These indices are measured non-invasively via ventilator maneuvers during standardized stepwise adjustments of pressure support ventilation (baseline, ±3 cmH₂O, ±6 cmH₂O, return to baseline). The mean of three repeated measurements at each step will be analyzed.
Time frame: Baseline and during protocol sessions, up to 3 days after enrollment
Incidence of ventilatory response patterns during PSV
Ventilatory response patterns will be categorized as quasi-passive or active based on physiological criteria derived from changes in tidal volume, plateau pressure, and PMI during stepwise PSV adjustments. Patterns will be determined from individual response trends.
Time frame: Baseline and during protocol sessions, up to 3 days after enrollment
Duration of mechanical ventilation after protocol
Time from completion of the PSV protocol until successful extubation, measured in hours. Reintubation within 48 hours will be recorded separately.
Time frame: Within 48 hours after extubation
Reintubation or non-invasive ventilation use
Proportion of patients requiring reintubation or initiation of non-invasive ventilation within 48 hours after extubation following study participation.
Time frame: 48 hours after extubation
ICU length of stay
Total number of days from ICU admission to ICU discharge.
Time frame: Through ICU stay, an average of 7-21 days
Hospital discharge disposition
Patient's status at hospital discharge (alive vs. deceased; home vs. rehabilitation vs. long-term care).
Time frame: Through hospital stay, an average of 14-60 days
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