Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort Study

N/ANot Yet RecruitingNCT07200999

Centre Hospitalier de Saint-Denis250 enrolled

Overview

This study looks at how common certain antibiotic-resistant bacteria (called extended-spectrum beta-lactamase-producing Enterobacteriaceae, or E-BLSE) are in pregnant women who experience premature breaking of their water before full term. The goal is to understand how often these bacteria are found, how long they stay, and what factors increase the risk of carrying them. This information will help doctors choose the best antibiotics to protect both the mother and baby from infections during and after pregnancy. The study follows women from the time of their membrane rupture until delivery, collecting samples to track the bacteria over time.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Premature Rupture of Membranes Enterobacteriaceae Beta-Lactams Drug Resistance, Bacterial Antibiotic Prophylaxis Pregnancy Intrauterine Infection

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria : * Pregnant women aged over 18 years * Diagnosed with premature rupture of membranes before term (between 23 weeks + 0 days and 36 weeks + 6 days of gestation) * Managed in one of the participating maternity hospitals Exclusion Criteria : * No available microbiological sample * Minors or women under legal guardianship (curatorship, tutelage, or judicial protection) * Women who refuse the use of their clinical data for research purposes at admission or within one month after receiving the information document

Outcomes

Primary Outcomes

The proportion of vaginal swabs (PV) positive for extended-spectrum beta-lactamase-producing Enterobacteriaceae (E-BLSE) in pregnant women with premature rupture of membranes before term, measured at diagnosis, during the latency period, and at delivery.

Time frame: 1 year