The clinical study aims to evaluate the safety and efficacy of umbilical cord blood transfusion in treating bone marrow suppression after chemotherapy in elderly patients with MDS and AML
The clinical study aims to evaluate the safety and efficacy of umbilical cord blood (HLA typing 0-3/10 match, TNC ≥ 3×10\^7/kg)transfusion in treating bone marrow suppression after chemotherapy in elderly patients with MDS and AML,UCB can be applied in one to multiple doses, and the minimum interval between two cord blood transfusions should be 2 weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Umbilical cord blood transfusion should be performed 24 hours to 2 weeks after chemotherapy. One to multiple units of cord blood can be applied, and the minimum interval between two cord blood transfusions should be 2 weeks.
Percentage of patients with bone marrow suppression grade < II.
Calculate the percentage of patients with bone marrow suppression grade \< II based on recorded hematological parameters.
Time frame: Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
hematological parameters like hemoglobin level(Hb)
Monitor and record hemoglobin level(g/L), every 2 days in patients, and maintain a record.
Time frame: Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
hematological parameters like white blood cell count(WBC)
Monitor and record white blood cell count( 10⁹/L)every 2 days in patients, and maintain a record.
Time frame: Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
hematological parameters like platelet count(PLT)
Monitor and record platelet count ( 10⁹/L)every 2 days in patients, and maintain a record.
Time frame: Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
hematological parameters like neutrophil count(ANC)
Monitor and record neutrophil count ( 10⁹/L)every 2 days in patients, and maintain a record.
Time frame: Tests should be conducted every two days after umbilical cord blood transfusion, for a maximum of 30 days.
Incidence of bleeding
To investigate the efficacy characteristics, percentages will be calculated.
Time frame: Up to 30 days after umbilical cord blood treatment
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Incidence of infection
To investigate the efficacy characteristics, percentages will be calculated.
Time frame: Up to 30 days after umbilical cord blood treatment.