A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea

N/ACompletedNCT07201571

Samsung Medical Center3,131 enrolled

Overview

This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery

Study Type

OBSERVATIONAL

Enrollment

3,131

Conditions

Oesophageal Squamous Cell Carcinoma

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who underwent curative surgery for esophageal cancer Exclusion Criteria: * cervical esophageal cancer * gastroesophageal junction cancer * histology other than squamous cell carcinoma * patients with Child-Pugh class B or C liver cirrhosis

Outcomes

Primary Outcomes

Postoperative complications

Complications related to fluid imbalance and portal hypertension, such as ascites, pleural effusion, and chyle leak; complications associated with impaired renal or hematologic function, including acute kidney injury, bleeding, and graft failure; and complications reflecting immune dysfunction and infection susceptibility, including pneumonia and empyema. Complications associated with impaired tissue healing, such as anastomotic leakage, were also analyzed. Liver failure and acute respiratory distress syndrome were considered separately. All complications were defined according to the Esophageal Complications Consensus Group, and their severity was assessed according to the Clavien-Dindo classification.

Time frame: within 90 days after surgery

Secondary Outcomes

Overall survival

Interval from the date of surgery to death or censoring

Time frame: 10 years after surgery

Data from ClinicalTrials.gov

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