Individuals with metabolic syndrome (MetS), particularly those with type 2 diabetes (T2D), and/or metabolic dysfunction-associated steatohepatitis or MASH face an elevated risk of major cardiovascular events (MACE). We showed decrease plams level of PPi in patients with liver cirrhosis. We hypothezised that liver transplant should block AC and restore PPi plasma level.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
95
The study is offered to all patients who meet the inclusion criteria during their pre-transplant assessment by the principal investigator (during an existing visit). Patients eligible for HT are contacted by a clinical research coordinator, and if they agree, an inclusion visit is arranged.
CHU de Nice
Nice, Alpes-maritimes, France
RECRUITINGhepatic transplantation reduces arterial calcification
compare the percent of patients with AC progression before and after liver tranplantation
Time frame: On the 7th day after surgery
identify arterial calcification related factors
separation of patients according to AC progression (yes or no) and machine learning analysis with all relevant factors
Time frame: On the 7th day after surgery
increase of PPi plasma level after liver transplantation
comparison of mean plasma levels before and after
Time frame: at inclusion and at 3 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.