This study aims to evaluate the clinical applicability of a peri-habilitation program in patients with gastric cancer by applying nutritional intervention for approximately two weeks before surgery and a combined exercise and nutrition intervention for about three weeks after hospital discharge, and by analyzing its effects on the prevention of postoperative complications and recovery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
30
Nutrition Group (NUT) Participants will receive standard clinical care combined with nutrition education and protein-enriched soy milk supplementation for approximately 2 weeks before surgery and about 3 weeks after hospital discharge.
Exercise and Nutrition Participants will receive peri-habilitation exercise training together with nutritional intervention, including carbohydrate plus protein-enriched soy milk supplementation twice daily (before and after exercise), for approximately 2 weeks before surgery and about 3 weeks after hospital discharge.
Anam Hospital
Seoul, seongbuk-gu, South Korea
Gait speed test
* Time to walk 4 meters (or 3 meters) at a normal, comfortable pace. * Seconds(sec) * Lower values(seconds) indicate better performance (faster walking speed)
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Chair stand test
* Time to stand up and sit down 5 times from a chair without using the arms. * Seconds(sec) * Lower values(seconds) indicate better performance.
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Balance test
* Time maintaining balance in three positions (feet together, semi-tandem, and tandem stance). The maximum time allowed for each position is 10 seconds. * Seconds(sec) * Higher values(seconds) indicate better performance.
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Timed up and go test
* Time to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. * Seconds(sec) * Lower values(seconds) indicate better performance.
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Electrocardiogram(ECG)
* Cardiovascular status assessed using electrocardiogram (ECG) * N/A (qualitative/clinical assessment) * Abnormal ECG findings indicate impaired cardiovascular function.
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Inflammation and Oxidative Stress Markers (Blood Analysis)
* Inflammatory and oxidative stress markers assessed by blood analysis, including C-reactive protein (CRP) and white blood cell(WBC) count. * mg/L for CRP; ×10⁹/L for WBC * Higher values indicate greater systemic inflammation.
Time frame: Baseline (2 weeks before surgery) Preoperative hospitalization (1-4 days before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Hospital Anxiety and Depression Scale (HADS)
* The scale ranges from 0 to 21 points for each domain (anxiety and depression). Higher scores indicate worse psychological distress. * Score on a scale (0-21) * Higher scores indicate worse psychological condition.
Time frame: Baseline (2 weeks before surgery) Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
Quality of life(KOQUSS-32, KOQUSS-40)
* Quality of life assessed using the Korean Quality of Life in Stomach Cancer Patient Study group questionnaires (KOQUSS-32 and KOQUSS-40). Each questionnaire provides domain-specific scores. Higher scores indicate better quality of life. * Score on a scale (range depends on quetionnaire) * Higher scores indicate better quality of life.
Time frame: Baseline (2 weeks before surgery) 3 weeks after discharge 6 months after surgery
Clavien-dindo classification
* Postoperative complications will be assessed and graded according to the Clavien-Dindo classification system (Grade I-V). * Number of participants with each complication grade. * Higher grades indicate more severe postoperative complications.
Time frame: Postoperative discharge (at hospital discharge) 3 weeks after discharge 6 months after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.