The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have obesity or overweight. SUI is leaking urine during movement or activity such as coughing or exercising. Participation in the study will last about 58 weeks from screening to safety follow-up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
1,000
Administered orally
Administered orally
Change from Baseline in Incontinence Episode Frequency (IEF)
Time frame: Baseline, Week 52
Percent Change from Baseline in Body Weight
Time frame: Baseline, Week 52
Change from Baseline in Urinary Incontinence-Specific Quality of Life
Time frame: Baseline, Week 52
Change from Baseline in Number of Continence Pad (CAPD) Used Per Week
Time frame: Baseline, Week 52
Change from Baseline in Patient Global Impression of Condition
Time frame: Baseline, Week 52
Percent Change from Baseline in Total Cholesterol
Time frame: Baseline, Week 52
Change from Baseline in Waist Circumference
Time frame: Baseline, Week 52
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
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