Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event

N/ARecruitingNCT07203443

Institut National de la Santé Et de la Recherche Médicale, France960 enrolled

Overview

CARE 13-11 study explores the transmission of trauma within families. Exposure to a traumatic event can have an impact on those directly exposed, but also on their family. This transmission is both biological and behavioral, leading to adaptation that is still poorly understood. CARE 13-11 project offers a unique opportunity to bring together different disciplinary fields, from neuroscience to human and social sciences, to understand this phenomenon. To answer these questions, the study includes directly exposed families with minor children born before the events, as well as families with no exposure to these events (the so-called "control" group).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

960

Conditions

Intergenerational Trauma

Interventions

Eligibility

Sex: ALLMin age: 9 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Exposed group Children * Minor child born before November 13, 2015 * At least one parent was present at the scene of the attacks: criteria A1 (directly exposed to the event) or exposed to the event) or A2 (witnessed the event) of DSM-5 * With a good command of the French language (francophone) * Whose parents have given written consent for their child's their child's participation * At least one parent is covered by health insurance Parent 1 (and Parent 3) * Parent of child(ren) included * Directly exposed to the attacks: present at the scene of the attacks: criteria A1 (directly exposed to the event) or to the event) or A2 (witness to the event) of the DSM-5 * Good command of the French language * Affiliated with or benefiting from a social security scheme * Has given written consent Parent 2 * Parent of child(ren) included * Not exposed but whose spouse (or ex-spouse) was directly exposed to the attacks on a declarative basis * Have a good command of the French language * Affiliated with a social security scheme or beneficiary of such a scheme * Having given written consent Uncle/aunt * Not exposed, but has a brother or sister directly exposed to the attacks * Have a good command of the French language * Beneficiary of health insurance * Having given written consent Cousin * Minor child born before November 13, 2015 * Whose aunt or uncle was directly exposed to the attacks * Child with a good command of the French language * Who has given written consent * Whose parents with parental authority have given written consent for their child's their child's participation * Whose parent is affiliated to a social security scheme or is a beneficiary of such a scheme Unexposed group Child * Minor child born before November 13, 2015 * No relative (family or close friend) has been exposed to the attacks * With a good command of the French language * Whose parents have given their written consent for their child's their child's participation * One of whose parents is affiliated to or benefits from a social security scheme Parent 1 * Parent of child(ren) included * No exposure to the attacks and no close relative (family or close friend) exposed to the attacks attacks * No PTSD at the time of inclusion (PCL-5 \< 33) * Have a good command of the French language * Affiliated with or benefiting from a social security scheme * Having given written consent Parent 2 * Parent of included child(ren) * No exposure to terrorist attacks * With a good command of the French language * Affiliated with or benefiting from a social security scheme * Having given written consent Exclusion Criteria: For all children: * Loss of both parents following the events of November 13 * Presence of a history of severe neurological, mental or psychopathological disorders (epilepsy, head trauma with loss of consciousness of more than one hour, autism spectrum disorder, intellectual disability, schizophrenia) * Persons subject to a legal protection measure (safeguard of justice, curatorship, guardianship) * Subject to a period of exclusion in the context of another research project * Refusal of the child to participate in research For children undergoing the on-site protocol: * Person with contraindications to MRI * For women of childbearing age, pregnancy in progress * Psychotropic products capable of modifying attention, vigilance and concentration taken less than 24 hours before questionnaires or examinations (sleeping pills and hypnotics, antipsychotics, mood regulators, antiepileptics and antihistamines). If in doubt about the patient's ability the patient's ability to postpone treatment, advice should be sought from the attending physician. in the case of antipsychotics and antiepileptics For all parents: * Presence of a history of neurological or neurodevelopmental disorders prior to the attacks except ADHD (epilepsy, head trauma with loss of consciousness of more than one hour, autism spectrum disorder autism spectrum disorder, intellectual disability, schizophrenia) * Persons subject to a legal protection measure (safeguard of justice, curatorship, guardianship) * Subject to a period of exclusion in the context of another research project * Parent's refusal to participate in research For parents carrying out the protocol on site: * Person with contraindications to MRI * For women of childbearing age, current or planned pregnancy * Psychotropic products capable of modifying attention, vigilance and concentration taken less than 24 hours before questionnaires or examinations (sleeping pills and hypnotics, antipsychotics, mood regulators, antiepileptics and antihistamines). If in doubt about the patient's ability the patient's ability to postpone treatment, advice should be sought from the attending physician. in the case of antipsychotics and antiepileptics

Outcomes

Primary Outcomes

Assessment of Psychiatric nosography with MINI (parents)

Psychological interview

Time frame: During the one day of assessments

Assessment of PTSD symptoms severity in children 8-11 years and 12-17 years

Results from CPSS-5 a semi-structered interview

Time frame: During the one day of assessments

Assesssment of PTSD symptoms for parents and children over the age of 18

Results from SCID-5-CV which is a semi-structered interview for the diagnosis of mental disorders DSM-5

Time frame: During the one day of assessments

Assessment of PTSD symptoms severity in adults

Scores from PCL-5 which is a self report measure

Time frame: During the one day of assessments

Secondary traumatisation

Parents and children : Scores from FST

Time frame: During the one day of assessments

Post-traumatic growth

Parents : Scores from PTGI

Time frame: During the one day of assessments

Coping skills for parents, children 12-17 years and over the age of 18

Scores from BCI

Time frame: During the one day of assessments

Coping skills for parents and children 8-11 years

Scores from SRCS.

Time frame: During the one day of assessments

Resilience for parents and children over the age of 18

Scores from ARM-R

Time frame: During the one day of assessments

Resilience for children 8 to 11 years old

Scores from CYRM-R-Child

Time frame: During the one day of assessments

Resilience for children 12 to 17 years old

Scores from CYRM-R-Youth

Time frame: During the one day of assessments

Attachment

Children : Scores from IPPA

Time frame: During the one day of assessments

Anxiety

Parents : scores from STAI

Time frame: During the one day of assessments

Depression

Parents : scores from BDI

Time frame: During the one day of assessments

Self-esteem

Parents : scores from SPP-Adult

Time frame: During the one day of assessments

Emotion regulation for parents and children over the age of 18

Scores from ERQ

Time frame: During the one day of assessments

Emotion regulation for Children and adolescents aged 8 to 17

Scores from ERQ-CA

Time frame: During the one day of assessments

Empathy for Parents, chidren 12-17 years and children over the age of 18

Scores from BES-A

Time frame: During the one day of assessments

Empathy for Children 8-11 years

Scores from BES-C

Time frame: During the one day of assessments

World vision

Parents and children : scores from WAS

Time frame: During the one day of assessments

Well being

Parents and children : score from WHO-5

Time frame: During the one day of assessments

Assessment of Psychiatric nosography with CBCL/YSR (children)

Total score, Main scales: Internalized behaviours, Externalized behaviours, Subscales: Anxiety/Depression, Social withdrawal, Somatic complaints, Interpersonal problems, Thought disorder, Attention deficit disorder, Deviant behaviours, Aggressive behaviours, Other problems

Time frame: During the one day of assessments

Social support

Parents : scores from Social Support Questionnaire

Time frame: During the one day of assessments

Cognitive avoidance

Parents and children : scores from QEC

Time frame: During the one day of assessments

Bonding

Parents and children : scores from PBI

Time frame: During the one day of assessments

Familial functionning

Parents and children :Scores from the FAD-SF

Time frame: During the one day of assessments

Parenting style and practices

Parents and children : Scores from the APQ

Time frame: During the one day of assessments

Communication about 13-11 Event

Parents and children : results from Communication about 13-11 Event Interview

Time frame: During the one day of assessments

Attention

Parents and children : scores from the Attentional Network Test

Time frame: During the one day of assessments

Transmission of traumatic memory

Parents and children : results from the Approach-Avoidance Task

Time frame: During the one day of assessments

Executive functionning

Children : scores from BRIEF

Time frame: During the one day of assessments

Cortisol

Parents and children : Cortisol Awakening Response

Time frame: During the morning of the one day of assessments

Sleep - questionnaires for children 8-11 and 12-17 years

Scores from SDSC

Time frame: During the one day of assessments

Sleep - questionnaires for Parents and children over the age of 18

Scores from PSQI

Time frame: During the one day of assessments

Sleep - questionnaires for Parents and children over the age of 18

Scores from ISI

Time frame: During the one day of assessments

Sleep - actimetry Parents and children

Measurement of bedtimes and wake-up times using an actimeter (a wrist-worn watch-size device).

Time frame: One week before the one day of assessments

Sleep - planner Parents and children

Evalustion of the sleep diary

Time frame: One week before the one day of assessments

Neuroanatomical analysis

Parents and children : anatomic MRI with the classic anatomical sequences

Time frame: During the one day of assessments

Neurofunctional analysis

Parents and children fonctionnal MRI with the measurement of the magnitude of the BOLD signal

Time frame: During the one day of assessments

Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes