FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
240
Supervised strength training 2x/week + self-administered cardio training 2x/week.
Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day.
Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen.
University of Copenhagen
Copenhagen, Copenhagen N, Denmark
RECRUITINGDNA-methylation age
Changes in predicted biological age from baseline based on DNA-methylation from isolated peripheral blood mononucleated cells after 52 weeks of intervention
Time frame: From enrollment until end of intervention at 52 weeks
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