Accelerated Transcranial Magnetic Stimulation Intervention for Post-Concussion Syndrome

N/ACompletedNCT07211919

Cognitive FX11 enrolled

Overview

This study looks at the effects of accelerated intermittent theta burst stimulation (aiTBS) on patients with chronic and acute post-concussion syndrome. Each participant was treated in an outpatient setting for about 3 hours per day, over 3 days. The participants' symptom survey scores and brain scan data were then compared before and after treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Post Concussive Syndrome, Chronic Post Concussion Symptoms Post Concussive Syndrome Post Concussion Syndrome Anxiety Disorder Not Otherwise Specified

Eligibility

Sex: ALLMin age: 16 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic or acute concussion symptoms Exclusion Criteria: * MDD, GAD, bipolar depression, PTSD, schizophrenia, metal implants in skull, pacemaker, history of seizures, epilepsy

Outcomes

Primary Outcomes

Post-Concussion Symptom Scale (PCSS) Score

PCSS (post-concussion symptom scale) is a 21-question Likert scale questionnaire regarding physical, cognitive, sleep, and emotional symptoms of post-concussion syndrome. Minimum score on the scale is zero, maximum score is 126. Higher score indicates more severe symptoms.

Time frame: Scores taken prior to intervention, immediately post-intervention, and 1-4 weeks post-intervention

Beck Anxiety Inventory (BAI) Score

Beck Anxiety Inventory is a 21-question Likert scale questionnaire used for measuring severity of anxiety symptoms. Minimum score is zero, maximum score is 63. Higher score indicates more severe symptoms.

Time frame: Immediately prior to treatment, after treatment, and 1-4 weeks post-treatment

Beck Depression Inventory (BDI) Score

Beck Depression Inventory is a 21-question multiple choice self-report inventory used for measuring severity of depression. Minimum score is zero, maximum score is 63. Higher scores indicate more severe symptoms.

Time frame: Pre-treatment, immediately post-treatment, and 1-4 weeks post-treatment.

Functional Neurocognitive Imaging (fNCI) Score

The fNCI assessment protocol combines the validity of conventional neuropsychological testing standards with the reliability and objectivity of informational data output provided by fMRI. It is a scan comparing BOLD signal and blood flow from participant's brain scan against a normative database of healthy, non-injured brains. Higher scores represent further deviation from healthy baseline, with a minimum score of zero and no theoretical maximum score. Scores below 1 are within healthy range.

Time frame: 1-4 weeks pre-treatment, 1-4 weeks post-treatment