This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
33
A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets.
Professional mechanical removal of supragingival plaque and calculus
Subgingival scaling and root planing
Selcuk University Faculty of Dentistry Department of Periodontology
Konya, Selçuklu, Turkey (Türkiye)
Probing Pocket Dept (PPD)
The probing pocket dept was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Time frame: Through study completion, an average of 3 months.
Periodontal Epithelial Surface Area (PESA)
PESA represents the total epithelial surface area in periodontal pockets.
Time frame: Through study completion, an average of 3 months.
Periodontal Inflamed Surface Area (PISA)
PISA quantifies the inflamed portion of this surface area by integrating only sites exhibiting BOP, both measured in mm2.
Time frame: Through study completion, an average of 3 months.
Salivary Malondialdehyde Levels
Evaluation of salivary malondialdehyde levels.
Time frame: Through study completion, an average of 3 months.
Salivary 8-hydroxy-2'-deoxyguanosine Levels
Evaluation of salivary 8-hydroxy-2'-deoxyguanosine levels.
Time frame: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PPD (ssPPD)
For sites with PPD ≥4 mm, site-specific PPD (ssPPD) values was calculated.
Time frame: Through study completion, an average of 3 months.
PPD ≥4 mm, site spesific CAL (ssCAL)
For sites with PPD ≥4 mm, site spesific CAL (ssCAL) values were also calculated.
Time frame: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PISA (ssPISA)
For sites with PPD ≥4 mm, site-specific PISA (ssPISA) values were calculated.
Time frame: Through study completion, an average of 3 months.
PPD ≥4 mm, site-specific PESA (ssPESA)
For sites with PPD ≥4 mm, site-specific PESA (ssPESA) values were calculated.
Time frame: Through study completion, an average of 3 months.
Plaque Index (PI)
The plaque index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Time frame: Through study completion, an average of 3 months.
Bleeding on Probing (BOP)
The bleeding on probing index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Time frame: Through study completion, an average of 3 months.
Clinical Attachment Level (CAL)
The clinical attachment level was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Time frame: Through study completion, an average of 3 months.
Gingival Index (GI)
The gingival index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Time frame: Through study completion, an average of 3 months.
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