This study will evaluate the long-term safety of pirtobrutinib in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is open to those who completed J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038) for continued access to the study intervention or continued follow-up visits. Treatment will be given every 4 weeks and this study is expected to last about 5 years.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Administered orally
Administered orally
Mitchell Cancer Institute
Mobile, Alabama, United States
RECRUITINGArizona Oncology Associates, P.C. - HOPE
Tucson, Arizona, United States
NOT_YET_RECRUITINGCancer Specialists, LLC
Jacksonville, Florida, United States
RECRUITINGMinnesota Oncology Hematology, P.A.
Coon Rapids, Minnesota, United States
Percentage of Participants with a Grade 3 or Higher Treatment-emergent Adverse Events (AEs)
Time frame: Time from First Dose of Study Intervention (Study Day 1) through 30 Days After Last Dose of Study Intervention or Start of New Anticancer Therapy, whichever is Earlier
Overall Survival
Overall survival is defined as the time from randomization in a randomized originator study, or from the first dose in a non-randomized originator study, until death from any cause
Time frame: Time from Enrollment in the Originator Study until Death from Any Cause (Up to 93 Months)
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Cayuga Cancer Center
Ithaca, New York, United States
NOT_YET_RECRUITINGMemorial Sloan-Kettering Cancer Center (MSKCC) - New York
New York, New York, United States
RECRUITINGOncology Hematology Care Inc
Cincinnati, Ohio, United States
NOT_YET_RECRUITINGTexas Oncology - Paris
Fort Worth, Texas, United States
NOT_YET_RECRUITINGUS Oncology - Texas Oncology
Kyle, Texas, United States
NOT_YET_RECRUITINGThe Alfred Hospital
Melbourne, Australia
NOT_YET_RECRUITING...and 40 more locations