NCT07219134 - Pilot Investigation of Dual Energy CT Imaging on an Online Adaptive Radiation Therapy System | Crick

Overview

This study is being done to see if researchers can find a better way to image a patient's tumor during radiation treatment.

Study Type

OBSERVATIONAL

Enrollment

30

Conditions

Genitourinary System Carcinoma Malignant Pelvic Neoplasm

Interventions

Non-Interventional StudyOTHER

Non-interventional study

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \* Patients with pelvis or genitourinary (GU) cancer requiring standard of care radiotherapy treatment * All adults, defined as individuals of 18 years of age or greater * Radiotherapy treatment will be performed on the Varian Ethos radiotherapy system * Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: * \* Minors, defined as individuals less than 18 years of age * Pregnant or nursing female

Locations (1)

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Image quality- Mean

The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT.

Time frame: Up to 2 years

Image quality- median

The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT.

Time frame: Up to 2 years