A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment

Change in Montreal Cognitive Assessment (MoCA) Total Score

The Montreal Cognitive Assessment (MoCA) is a validated screening tool for mild cognitive impairment. It assesses multiple cognitive domains including attention, executive functions, memory, language, visuospatial skills, conceptual thinking, calculation, and orientation. The test takes approximately 10 minutes to administer and is scored out of a maximum of 30 points. The total score is calculated by summing all sub-item scores, with an additional 1 point added for individuals with ≤12 years of education (maximum score remains 30). Higher scores indicate better cognitive performance. A score below 23 for individuals with ≤12 years of education, or below 22 for those with \>12 years of education, is considered indicative of cognitive impairment \[Wu et al., 2013\].

Time frame: From baseline to Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Cognitive Function Using Trail Making Test (TMT) Parts A and B

The Trail Making Test (TMT) is a neuropsychological assessment that provides information on visual search, scanning, processing speed, mental flexibility, and executive functioning. It consists of two parts. Both parts consist of 25 circles distributed over a sheet of paper. In Part A, the circles are numbered 1 - 25, and the patient should draw lines to connect the numbers in ascending order. In Part B, the circles include both Arabic numerals (1 - 13) and Chinese numerals as in Part A. he test is administered on paper, and participants are instructed to complete the task as quickly and accurately as possible without lifting the pen. Performance is measured in seconds.

Time frame: Change from baseline to Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Cognitive Processing Speed Using Symbol Digit Modalities Test (SDMT)

The Symbol Digit Modalities Test (SDMT) is a validated neuropsychological test used to assess cognitive processing speed, attention, and visual-motor coordination. Participants are presented with a series of symbols, each paired with a digit, and are asked to match as many symbols to their corresponding digits as possible within a fixed time period (typically 90 seconds). Performance is measured by the number of correct symbol-digit matches completed (maximum 110). Higher scores indicate better cognitive processing speed and attention

Time frame: Change from baseline to Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Verbal Fluency Performance Using Verbal Fluency Test (VFT)

The VFT tests the verbal fluency, the patient is asked to name as many examples of one category, e.g. "fruits", "vegetables", "animal", as possible within one minute. Performance is assessed by counting the number of correct, non-repeated words, along with the number of errors, including incorrect responses and repetitions, which contribute to the total score. Higher scores indicate better verbal fluency and cognitive function.

Time frame: Change from baseline to Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Clinical Global Impression of Change Using ADCS-CGIC (Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change)

The Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change (ADCS-CGIC) is a validated clinician-rated instrument used to assess overall change in a participant's cognitive, functional, and behavioral status over time. It is based on a structured interview with both the participant and caregiver, incorporating clinical judgment and observation. The ADCS-CGIC uses a 7-point scale to rate change from baseline: 1. \- Marked improvement 2. \- Moderate improvement 3. \- Minimal improvement 4. \- No change 5. \- Minimal worsening 6. \- Moderate worsening 7. \- Marked worsening Lower scores indicate improvement, while higher scores reflect deterioration.

Time frame: Change from baseline to Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Neurological Impairment Using National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a standardized tool used to assess the severity of neurological deficits in patients following a stroke. It consists of 11 items evaluating functions such as consciousness, vision, motor skills, sensation, language, and attention. Each item is scored individually, and the total score ranges from 0 to 42, with higher scores indicating more severe neurological impairment. A decrease in score over time reflects improvement in neurological function, while an increase indicates worsening impairment.

Time frame: Change from Baseline to Week 4 (Visit 1), Week 26 (Visit 4) and Week 52 (Visit 6)

Change in Neurological Impairment Using Modified Rankin Scale (mRS)

The Modified Rankin Scale (mRS) is a clinical tool for measuring the degree of disability or dependence in daily activities of people who have suffered a stroke. It assesses functional recovery and neurological impairment on a scale ranging from 0 to 6: 0 - No symptoms at all 1. \- No significant disability despite symptoms; able to carry out all usual duties and activities 2. \- Slight disability; unable to carry out all previous activities but able to look after own affairs without assistance 3. \- Moderate disability; requiring some help, but able to walk without assistance 4. \- Moderately severe disability; unable to walk without assistance, and unable to attend to own bodily needs without assistance 5. \- Severe disability: bedridden, incontinent, and requiring constant nursing care and attention 6. \- Dead Lower scores indicate better functional outcomes.

Time frame: Change from Baseline to Week 4 (Visit 1), Week 26 (Visit 4) and Week 52 (Visit 6)

Any new stroke event (ischemic stroke or hemorrhagic stroke) at Week 4, Week 12, Week 26, Week 38 and Week 52.

Time frame: Week 4, Week 12, Week 26, Week 38 and Week 52