The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room
Patients will receive 0.3mg/kg methadone intravenously after induction of general anesthesia
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Amount of opioid medication used 72 hours post-extubation
Opioid medication used at 72 hours post-extubation will be reported in morphine milligram equivalents
Time frame: From hospital admission for surgery to 72 hours after the patient is extubated postoperatively
Amount of opioid medication used 24 hours post-extubation
Opioid medication used at 24 hours post-extubation will be reported in morphine milligram equivalents
Time frame: From hospital admission for surgery to 24 hours after the patient is extubated postoperatively
Amount of opioid medication used 48 hours post-extubation
Opioid medication used at 48 hours post-extubation will be reported in morphine milligram equivalents
Time frame: From hospital admission for surgery to 48 hours after the patient is extubated postoperatively
Amount of opioid medication required throughout hospitalization
Opioid medication required from extubation until hospital discharge will be reported in morphine milligram equivalents
Time frame: From the time the patient is extubated until the time the patient leaves the hospital, approximately 10 days. Safety to leave the hospital is determined by the cardiac surgery team and can be several days after surgery or longer.
Amount of opioid medication required prior to extubation
Opioid medication required between the end of surgery and extubation will be documented in morphine milligram equivalents.
Time frame: From arrival in the ICU until extubation, approximately 6 hours. Safety of extubation is determined by the intensive care unit team and usually occurs within several hours of ICU arrival, although this can be variable.
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Pain scores after extubation
Pain will be assessed by nursing staff using a numerical rating scale from 0-10, with 0 being no pain and 10 being the worst pain imaginable.
Time frame: 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours after extubation
Time to extubation
This outcome will monitor the time in minutes from when a patient arrives in the ICU to the time the breathing tube is removed (extubation).
Time frame: From the time the patient arrives in the ICU intubated until the time they are successfully extubated, approximately 12 hours. Safety of extubation is determined by the ICU team and usually occurs within several hours, although this can be variable.