tFUS Imaging & LIFU

Virginia Polytechnic Institute and State University

Overview

This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).

A battery of tasks will be performed under two imaging conditions. Magnetic Resonance Imaging and transcranial functional ultrasound imaging. Tasks include a breath hold task, an e-stim task, and low-intensity focused ultrasound neuromod.

Study Type

INTERVENTIONAL

Allocation

Purpose

DEVICE_FEASIBILITY

Masking

NONE

Conditions

Brain Imaging

Interventions

Feasibility of imaging using tFUSDEVICE

Imaging using transcranial functional ultrasound.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * See above. Exclusion Criteria: * Claustrophobia * Contraindications to MRI (neurostims, metal implants, pacemakers, etc) * Contraindications to CT (pregnancy) * Active medical disorders with CNS effects (e.g. Alzheimers) * History of neurological disorder * History of head injury with LOC \> 10 min * History of alcohol or drug dependence

Locations (1)

Fralin Biomedical Research Institute at VTC

Roanoke, Virginia, United States

Outcomes

Primary Outcomes

Detecting task-evoked changes

Detecting task-evoked changes using tFUS imaging

Time frame: The duration of each task - ~10 minutes.

Secondary Outcomes

Detecting LIFU induced neural activity

Detection in changes of neural activity during LIFU using tFUS

Time frame: During LIFU application, ~2 min.

Data from ClinicalTrials.gov

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