The purpose of this study is to evaluate the safety, tolerability, and efficacy of BMS-986523 alone and in combination with anti-cancer agents in participants with advanced solid malignancies
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
252
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Johns Hopkins Hospital
Baltimore, Maryland, United States
RECRUITINGNEXT Oncology
San Antonio, Texas, United States
RECRUITINGSTART Mountain Region
West Valley City, Utah, United States
RECRUITINGNEXT Virginia
Fairfax, Virginia, United States
RECRUITINGBC Cancer Vancouver
Vancouver, British Columbia, Canada
RECRUITINGPrincess Margaret Cancer Centre
Toronto, Ontario, Canada
RECRUITINGLocal Institution - 0006
Badalona, Barcelona [Barcelona], Spain
NOT_YET_RECRUITINGLocal Institution - 0008
Hortaleza, Madrid, Spain
NOT_YET_RECRUITINGNumber of participants with adverse events (AEs)
Time frame: Up to 3 years
Number of participants with serious adverse events (SAEs)
Time frame: Up to 3 years
Number of participants with AEs meeting protocol-defined dose limiting toxicity (DLT) criteria
Time frame: Up to 3 years
Number of participants with AEs leading to discontinuation
Time frame: Up to 3 years
Number of deaths
Time frame: Up to 3 years
Objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 as assessed by the investigator.
Time frame: Up to 3 years
Duration of response (DOR) per RECIST v1.1 as assessed by the investigator.
Time frame: Up to 3 years
Maximum observed plasma concentration (Cmax)
Time frame: Up to 3 years
Time of maximum observed plasma concentration (Tmax)
Time frame: Up to 3 years
Area under the concentration-time curve in 1 dosing interval (AUC(TAU))
Time frame: Up to 3 years
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
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