This study aims to compare 28-day mortality among patients with carbapenem resistant A. baumannii infections in two hypothetical target trials where patients receive 7 days of a cefiderocol-based treatment strategy or 7 days of a best available therapy treatment strategy.
please see uploaded study protocol
Study Type
OBSERVATIONAL
Enrollment
5,000
National Institutes of Health Clinical Center
Bethesda, Maryland, United States
Mortality
In hospital mortality or discharge to hospice during the hospital stay
Time frame: During inpatient admission
Length of Stay
Duration of hospitalization among surviving patients
Time frame: Inpatient admission
Recurrent CRAB Infection
clinical culture positive for carbapenem-resistant A. baumannii (CRAB) infection within the same encounter downstream of the index episode and within 30 days.
Time frame: Within 30 days post discharge
Development of antibiotic resistance to initial antibiotic treatment
Development of antibiotic resistance on a subsequent positive clinical culture to an antibiotic administered during prior infectious episode
Time frame: Subsequent admissions
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