The main purpose of this study is to evaluate safety and efficacy, and measure how much LY4584180 gets into the bloodstream and how long it takes the body to eliminate it in patients with previously treated blood cancers. For each participant, the study could last about 9 months or possibly longer including screening.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
460
Number of Dose-Limiting Toxicities (DLTs) and DLT-Equivalent Toxicities
Number of Dose-Limiting Toxicities (DLTs) and DLT-Equivalent Toxicities
Time frame: Baseline up to Day 28
Number of Participants with One or More Serious Adverse Events (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Number of Participants with One or More Serious Adverse Events (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Time frame: Baseline up to 3 Years
To Evaluate the Preliminary Antitumor Activity of LY4584180: Objective Response Rate (ORR)
To Evaluate the Preliminary Antitumor Activity of LY4584180: Objective Response Rate (ORR)
Time frame: Baseline up to 3 Years
Pharmacokinetics (PK): Maximum Serum Concentration (Cmax) of LY4584180
PK: Cmax of LY4584180
Time frame: Baseline to Day 8
PK: Area Under the Concentration (AUC) Versus Time Curve of LY4584180
PK: AUC versus time curve of LY4584180
Time frame: Baseline to Day 8
Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Mayo Clinic - Scottsdale
Scottsdale, Arizona, United States
RECRUITINGCity of Hope
Duarte, California, United States
RECRUITINGUniversity of California, Los Angeles (UCLA) - Medical Center
Los Angeles, California, United States
RECRUITINGUniversity of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
RECRUITINGColorado Blood Cancer Institute
Denver, Colorado, United States
RECRUITINGUniversity of Miami - Sylvester Cancer Center
Miami, Florida, United States
RECRUITINGFlorida Cancer Specialists - Sarasota
Sarasota, Florida, United States
RECRUITINGEmory University Hospital
Atlanta, Georgia, United States
RECRUITINGMassachusetts General Hospital
Boston, Massachusetts, United States
RECRUITINGDana-Farber Cancer Institute
Boston, Massachusetts, United States
RECRUITING...and 36 more locations