This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion. Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine. Outcomes include opioid consumption over 72 hours, pain scores, length of stay, and time to ambulation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
75
Cervical and lumbar ESP blocks performed under ultrasound guidance using plain bupivacaine.
Cervical and lumbar ESP blocks performed under ultrasound guidance using bupivacaine admixed with liposomal bupivacaine.
Duke University
Durham, North Carolina, United States
Postoperative Pain as measured by opiate consumption
Morphine MilliEquivalents
Time frame: 72 hours
Postoperative Pain at rest and with movement as measured by patient reported pain scores
Numeric Rating Scale (0-10)
Time frame: 4, 8, 12, 24, 48, and 72 hours
Discharge Readiness
Hospital and PACU Length of Stay
Time frame: 72 hours
Postoperative Pain Severity as measured by required time for patient controlled-analgesia
Duration of patient controlled analgesia use
Time frame: 72 hours
Incidents of post-operative nausea and vomiting
Post-operative Nausea and Vomiting
Time frame: 72 hours
Time to first ambulation
Time frame: 72 hours
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