Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired blood vessel function and excessive cellular damage from oxygen-containing molecules cause these dangerous blood pressure responses during exercise. The findings will establish whether targeting cellular antioxidant systems represents a new therapeutic approach to improve exercise tolerance and reduce cardiovascular risk in t Americans living with diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
40
During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ.
During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ, while the other they will ingest a placebo
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Mean Arterial Pressure
Change in mean arterial pressure is measured in response to handgrip exercise and post-exercise circulatory occlusion
Time frame: Prior to and 45 minutes following supplement
Heart Rate
Change in heart rate is measured in response to handgrip exercise and post-exercise circulatory occlusion
Time frame: Prior to and 45 minutes following supplement
Brachial Artery FMD
Brachial artery FMD a measure of endothelial function will be measured on the non-dominant arm
Time frame: Prior to and 45 minutes following supplementation
Plasma MitoQ Concentration
Circulating concentrations of MitoQ is assessed in blood via venipuncture
Time frame: Prior to and 45 minutes following supplementation
Muscle Tissue Oxygenation
We will also place a near-infrared spectroscopy (NIRS) pad on the thenar eminence of the non-paretic hand to non-invasively measure tissue oxygenation via infrared light following the pneumatic forearm cuff inflation/deflation.
Time frame: Prior to and 45 minutes following supplementation
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