Pilot Study on a Dietary Supplement With EndoGen™ as Adjunct Therapy in Women With Endometriosis

Inclusion Criteria for the Initial Run-In Phase 1. Written informed consent, signed and dated personally by the patient. 2. Female between the ages of 18 and 45 (including limits), with no race limitation. 3. Documented endometriosis, confirmed by laparoscopy, ultrasound, or MRI, with or without biopsy, performed up to 36 months prior to the start of this investigation and independently of it. 4. Stable health condition and stable drug treatments within the past 2 months. 5. Endometriosis with a grade 2 (mild) to grade 4 (severe) AFSr score, whether or not treated with sex hormones, contraceptives, or any other specific treatment, stable for a minimum of 2 months. Note: In a first phase of the investigation, patients in class 2 and 3 will be recruited, while in a second phase, patients in class 4 will also be recruited. 6. 10-point Visual Analogue Scale (VAS) score of pain due to endometriosis of at least 4 for at least 2 days in the 4 weeks prior to run-in. Inclusion criteria for treatment initiation Patients will start treatment with EndOK Green if they meet all of the following criteria. 1. Negative urine pregnancy test. 2. Difference, for at least two days, of no more than 10 in the 10-point Visual Analogue Scale (VAS) (10%) between the 4 weeks prior to the screening visit and the end of the run-in phase, provided that at least one menstruation occurred in the period. 3. No change in background therapy. Exclusion Criteria Patients will be excluded if they meet even one of the following criteria: 1. Pregnancy, breastfeeding, or intending to become pregnant during the time this investigation will be conducted. 2. Absence of cycles for at least 3 months. 3. Previous hysterectomy or oophorectomy. 4. Pelvic inflammatory disease regardless of its etiology (Chlamydia Trachomatis, Neisseria gonorrhoeae, fungi, etc.) or presence of ovarian cysts. 5. Known hypersensitivity or allergy to the active substances and/or any component of the product under investigation. 6. Patient who has taken, within 4 weeks prior to inclusion, or is currently taking, dietary supplements for the treatment of pelvic pain or other symptoms of endometriosis. 7. Participation in any clinical study that has been ongoing or concluded for less than three months. 8. Patient with one or more psychiatric disorders, such as alcoholism, substance abuse or addictive disorder, bipolar disorder, schizophrenia, or other personality disorders. 9. Patient who, in the opinion of the gynecologist, will not be able to meet the prerequisites required for this investigation.