A Trial of Itraconazole Effect on HRS-8080 Pharmacokinetics in Healthy Participants

Inclusion Criteria: 1. Aged 18-55 years; 2. Male weight ≥ 50 kg, female weight ≥ 45 kg, and body mass index (BMI): 19-28 kg/m2; 3. Normal or no clinically significant medical history, ECGs, vital signs and laboratory tests; 4. Take contraception. Exclusion Criteria: 1. Any serious clinical diseases or medical history or diseases that affect the absorption, metabolism and/or excretion of the study drug; 2. Severe infection, severe trauma or major surgery; 3. Any medications in the two weeks before screening or baseline period; 4. History of blood donation or severe blood loss; 5. Have been vaccinated within 3 months before the screening or baseline period; 6. History of smoking or excessive alcohol or drug abuse; 7. History of excessive amounts of tea, coffee or caffeinated beverages, special foods; or have special dietary requirements; 8. Other situations in which the researcher judges unsuitable.