The study is a Phase II study to explore the efficacy and safety of SHR-A2102 in combination with other anti-tumor therapies as perioperative treatment in patients with resectable non-small cell lung cancer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
RECRUITINGPathology complete response (pCR)
Time frame: Up to approximately 20 weeks.
18-month event free rate
Time frame: Up to approximately 18 months.
2-years disease free rate
Time frame: Up to approximately 2 years.
Event free survival (EFS)
Time frame: Up to approximately 5 years.
Overall survival (OS)
Time frame: Up to approximately 5 years.
Objective response rate (ORR)
Time frame: Up to approximately 20 weeks.
Disease-Free Survival (DFS)
Time frame: Up to approximately 5 years.
Adverse events (AEs)
Time frame: Up to approximately 5 years.
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Carboplatin.
Alomnertinib Mesilate.
Furmonertini Mesilate.
Osimertinib Mesylate.