To investigate the effects of Dronabinol use on blood pressure and neurovascular physiology
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
50
Patients will take one 10 mg dose of Dronabinol.
Patients will take one 10mg dose of a Placebo Pill.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Blood Pressure
Blood pressure is the force exerted by circulating blood on the walls of the arteries as it is pumped through the body. Blood pressure will be measured as a ratio of systolic/diastolic (mmHg).
Time frame: Baseline, 30 days
Heart Rate
Heart Rate is the number of contractions (beats) that the heart makes per minute. This will be measured in bpm (beats per minute)
Time frame: Baseline, 30 days
Baroreflex Sensitivity
Baroreflex sensitivity will be assessed using beat-by-beat blood pressure, heart rate, and Sympathetic nerve activity collected continuously for at least 5min. This will be measured in ms/mmHg.
Time frame: Baseline, 30 days
Sympathetic control
Sympathetic control will be measured by microneurography of peroneal or fibular nerve, reported as bursts of sympathetic activity per minute or normalized to 100 heart beats
Time frame: Baseline, 30 days
Flow Mediated Dilation
Flow Mediated Dilation will be measured by ultrasonography of brachial artery, reported as an absolute change in arterial diameter from resting baseline
Time frame: Baseline, 30 days
Aortic Wave Reflection
Aortic Wave Reflection will be measured via arterial tonometry, reported as aortic augmentation index
Time frame: Baseline, 30 days
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