Neuropsychological Profile Characterization in Patients With Migraine: Cognitive Functioning and Psychological Variables

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta150 enrolled

Overview

The overall objective is to define the neuropsychological profile of patients with migraine and evaluate its association with: psychological outcome measures (anxiety-depressive symptoms, pain catastrophizing, excessive worry, and coping strategies); the clinical profile of migraine; the prodromal, ictal, or interictal phase of the migraine attack; pharmacological therapy; and detoxification treatment in patients with migraine associated with medication overuse headache.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Migraine Migraine Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent. * Patients aged between 18 and 65 years. * Diagnosis of migraine according to the International Classification of Headache Disorders (ICHD-3) criteria. * Patients with a history of migraine for at least one year, to ensure the stability of the condition. * Stability of ongoing treatment for at least 3 months at baseline. * Understanding of the Italian language. Exclusion Criteria: * Severe medical or psychiatric conditions (depression, schizophrenia, psychosis) documented by specific previous diagnoses. * A history of alcohol or drug abuse. * Primary sensory deficits.

Locations (1)

Outcomes

Primary Outcomes

Cognitive functioning

Neuropsychological test scores in migraine patients and proportion of participants with cognitive performance significantly different from age- and education-adjusted normative data.

Time frame: 2 years

Secondary Outcomes

Cognitive functions and psychological, clinical aspects

Correlation between cognitive performance scores and validated measures of anxiety/depression, pain catastrophizing, worry, coping strategies, headache-related impact and disability, and sleep quality in migraine patients.

Time frame: 2 years

Cognitive functions and different pharmacological treatments

Differences in cognitive test performance scores among groups of migraine patients receiving different pharmacological treatments

Time frame: 2 years

Cognitive functions and medication overuse headache

Change in cognitive test performance scores from pre-detoxification to post-detoxification treatment in patients with migraine and medication overuse headache.

Time frame: 2 years

Cognitive functions in the different phases of migraine

Comparison of cognitive test performance scores between ictal and interictal migraine phases and across different durations of disease.

Time frame: 2 years