A Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting

Bayer2,000 enrolled

Overview

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a serious and life-threatening condition where a protein called transthyretin (TTR) misfolds and builds up as amyloid fibrils in the heart muscle. This buildup causes the heart to become stiff, leading to restrictive cardiomyopathy and progressive heart failure. There are two forms of ATTR-CM: a hereditary or 'variant' form (vATTR-CM) caused by a gene mutation, and a 'wild-type' form (wtATTR-CM) which is associated with aging. Because its symptoms can be similar to other heart conditions, ATTR-CM is often diagnosed late. However, recent advances in medical imaging are helping doctors to identify the disease earlier. Acoramidis is a new medication designed to treat ATTR-CM. It works by stabilizing the TTR protein, preventing it from misfolding and forming the harmful amyloid deposits. Acoramidis has been shown to be effective and safe in a major clinical trial (the ATTRibute-CM study), which led to its approval for use in both the United States and Europe. While clinical trials provide valuable information, data on how a new medicine performs in everyday clinical practice is also very important. This type of information is called real-world evidence. Currently, there is limited real-world information about the use of acoramidis. This study, called ACO-REAL, is an observational study, which means researchers will observe patients who are receiving acoramidis as part of their normal clinical care, without introducing any experimental interventions. The study will take place in approximately 20 European countries and aims to enroll up to 2,000 adults who have been diagnosed with either wild-type or variant ATTR-CM and are starting treatment with acoramidis. This includes patients who have not been treated for ATTR-CM before, as well as those who have been treated with other therapies. The main goals of the study are to understand the characteristics of patients being treated with acoramidis and to document how the treatment is used in routine medical practice. The study will also collect information on the safety of acoramidis. Furthermore, researchers will assess how the treatment affects patients' heart function, their functional capacity (such as their ability to walk), their overall health status, and their quality of life. The study will also track how often patients need to use healthcare resources like hospitals or emergency rooms. This information will help to improve the understanding and management of ATTR-CM in a real-world setting, ultimately aiming to optimize care for patients with this progressive disease.

Study Type

OBSERVATIONAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \- Adults (≥18 years at the date of signing the informed consent form (ICF)). * Diagnosis of either wild-type or variant ATTR-CM. * Signed ICF. * Decision to initiate treatment with acoramidis was made as per treating investigator's routine treatment practice before signature of ICF. * Treatment start with acoramidis within 90 days after signing the ICF, with the possibility of starting acoramidis on the same day as signing the ICF. Exclusion Criteria: * Participation in an investigational trial with interventions outside of routine clinical practice, except for participation in potential sub-studies related to this observational study. Please note: In addition to this observational study, separate sub-studies may be conducted to collect additional data. Participation in these sub-studies is voluntary and will be governed by separate protocols and informed consent processes. The main observational study does not include interventional procedures beyond routine clinical practice. * Contra-indications according to the local SmPC of acoramidis. * Patients who are unable to provide consent, including those whose consent would need to be given by a legal representative.

Outcomes

Primary Outcomes

Patient demographic characteristics: age

Demographic characteristics at the first documented regular visit in the study, referred to as the initial study visit.

Time frame: Baseline (Initial study visit)

Patient demographic characteristics: sex

Demographic characteristics at the first documented regular visit in the study, referred to as the initial study visit.

Time frame: Baseline (Initial study visit)

Patient demographic characteristics: race

Demographic characteristics at the first documented regular visit in the study, referred to as the initial study visit.

Time frame: Baseline (Initial study visit)

Patient demographic characteristics: height

Demographic characteristics at the first documented regular visit in the study, referred to as the initial study visit.

Time frame: Baseline (Initial study visit)

Patient demographic characteristics: weight

Demographic characteristics at the first documented regular visit in the study, referred to as the initial study visit.

Time frame: Baseline (Initial study visit)

Clinical Characteristics: Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Type

ATTR-CM type: mixed phenotype (yes/no)