Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial
Digital count of e.faecalis before and after application of different type of intra canal medication
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week
Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week
Trple antibiotic paste Left for one week
Al-Azhar University faculty of dental medicine
Cairo, Egypt
Digital count of e.faecalis
Microbiological evaluation The number of E. faecalis will be digitally counted.
Time frame: After One week of mediation application
Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility
Clincal success will be assessed using following criteria of success according to clinical scoring system Absence of : * Pain, * Soft tissue swelling * soft tissue inflammation * Sinus tract * tenderness to percussion * tooth mobility. Clinical score Clinical symptom Definition 1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm 2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \> 1mm, but \<2mm 3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \> 2mm, but \< 3 mm 4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology
Time frame: After one week of mediation application
Radiographic evaluation
After tweleve months take periapical radiograph to detection normal lamina dura and increase in root thikness and length. Criteria for success according to radiographic scoring system
Time frame: After tweleve month
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