Progression Patterns of Choroidal Venous Alterations

Singapore National Eye Centre250 enrolled

Overview

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Pachychoroid Disease

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adults aged 45 years or older. 2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant. 3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes 4. Willing to provide written informed consent Exclusion Criteria: 1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period 2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery) 3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders 4. Pregnant or nursing women 5. Persons who are unable to give informed consent

Locations (4)

Hong Kong University

Hong Kong, Hong Kong

NOT_YET_RECRUITING

University of Malaya Medical Centre

Kuala Lumpur, Malaysia

RECRUITING

National University Hospital, Singapore

Singapore, Singapore

NOT_YET_RECRUITING

Outcomes

Primary Outcomes

Progression of choroidal venous alterations

Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.

Time frame: 3 years

Secondary Outcomes

Incidence of progression of pachychoroid disease manifestation

New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.

Time frame: 3 years

Risk factors associated with progression of choroidal venous alteration

Assessment of demographic, cilinical, and imaging parameters associated with progression.

Time frame: 3 years

Central Contacts

Gemmy Cheung

CONTACT

+65 63227460 gemmy.cheung.c.m@singhealth.com.sg

Data from ClinicalTrials.gov

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