CVL Risk After Severe Glaucoma Surgery

N/AActive Not RecruitingNCT07237555

Gangnam Severance Hospital523 enrolled

Overview

This retrospective cohort study analyzes risk factors for central visual loss (CVL) after severe-stage glaucoma surgery. The primary hypothesis is that 1) visual prognosis is determined primarily by early postoperative intraocular pressure (IOP) stability rather than surgical choice, and 2) the nature of risk (hypotony vs hypertension) is modified by baseline visual reserve. We analyzed outcomes in 523 patients with severe-stage glaucoma who underwent trabeculectomy or Ahmed glaucoma valve (AGV) implantation, focusing on the dichotomous risk profile stratified by baseline visual acuity.

Study Type

OBSERVATIONAL

Enrollment

523

Conditions

Severe-stage Glaucoma (Mean Deviation ≤ -20 dB)

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Patients who underwent trabeculectomy or Ahmed glaucoma valve implantation at Yonsei Medical Center between January 2005 and October 2024. 2\. Glaucoma patients who underwent static quantitative perimetry (visual field test) before and after surgery. 3\. Patients with a preoperative Mean Deviation (MD) of ≤ -20 dB. Exclusion Criteria: * 1\. Patients who were unable to undergo visual field testing due to poor preoperative visual acuity. 2\. Patients with central visual field defects caused by retinal or neurological diseases other than glaucoma. 3\. Patients with false-positive or false-negative responses ≥33% on visual field testing.

Locations (1)

Gangnam Severacne Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Central Visual Loss (CVL) at 3 months postoperatively

Central visual loss defined as any of the following at 3 months postoperatively: (i) best-corrected visual acuity (BCVA) ≤ 20/200; (ii) decrease of ≥ 4 Snellen lines from baseline; or (iii) further deterioration of BCVA in eyes with preoperative BCVA ≤ 20/200.

Time frame: At 3 months postoperatively

Data from ClinicalTrials.gov

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