This project aims at unravelling mechanisms by which exposure to air pollution (in particular Ultrafine Particulate (UFP, PM0.1), and micro nano plastic's) interferes with the normal foetus development, with a short-term causal effect in higher likeliness of preterm delivery which, in consequence, precondition a higher likeliness to suffer non-communicable diseases (NCD) later in the life.
The characteristics of this study population are as follows: 1. Case-control design The study includes 1600 participants, providing a substantial sample for analysis. The focus is on newborns (age 0), making the study particularly relevant for understanding factors and outcomes related to this very early stage of life. The sex of the participants is expected to be randomly distributed. A control arm of full-term neonates (\>37 weeks) will be recruited for a 1:2 ratio in Greece and Spain. 2. Personal Exposure Monitoring PEM Substudy: The study consists of 150 mothers, with 50 from each location. All participants are females aged over 18 years. The sex of the participants is expected to be randomly distributed.
Study Type
OBSERVATIONAL
Enrollment
1,600
Instituto de Investigación Sanitaria La Fe
Valencia, Valencia, Spain
RECRUITINGPreTerm Birth
Time frame: at the moment of birth
Small for Gestational Age
Time frame: at the moment of birth
Low Birth Weigth
Time frame: at the moment of birth
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