A Prospective Cohort Study on Patient With Obesity Undergoing Weight Change

Inclusion Criteria: 1. Adults aged 18 years or older, regardless of gender. 2. Body mass index (BMI) ≥ 27 kg/m², or ≥ 24 kg/m² with one or more obesity-related comorbidities. 3. Willing to undergo any form of weight loss intervention. 4. Able to read and understand Chinese, willing to complete questionnaires, blood tests, and follow-up follow-up. 5. Voluntarily consent to participate and be willing to complete the subject consent form. Exclusion Criteria: 1. Pregnant or breastfeeding women. 2. Individuals with significant mental illness (e.g., schizophrenia, severe depression) or cognitive impairment that may affect their ability to consent or cooperate with the study. 3. Individuals with severe organ dysfunction (e.g., end-stage renal disease, cirrhosis, congestive heart failure, etc.). 4. Individuals taking medications that significantly affect their weight (e.g., long-term steroids or antipsychotics) and cannot be discontinued. 5. Individuals deemed unsuitable for participation in this study by the study leader (e.g., individuals who are expected to be unable to complete follow-up).