BMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement

N/AActive Not RecruitingNCT07240493

Aya Adil Saeed24 enrolled

Overview

This randomized controlled clinical trial aims to evaluate the effect of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) on the stability and marginal bone level of dental implants following immediate placement. patients requiring extraction of unrestorable tooth in upper incisors or premolar region will be randomly assigned into two groups: the experimental group will receive immediate implant placement with rhBMP-2 application, while the control group will receive immediate implant placement without rhBMP-2. each group includes 16 immediate implants. Implant stability will be assessed using resonance frequency analysis (RFA) at baseline, and 16 weeks after implant placement. Marginal bone level changes will be evaluated radiographically using cone beam computed tomography (CBCT). The study aims to determine whether the use of rhBMP-2 enhances osseointegration and reduces marginal bone loss compared with conventional immediate implant placement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Unrestorable Tooth Replaced by Immediate Implant With BMP

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Healthy patients ≥18 years of either sex, having a single or multiple unrestorable maxillary anterior and premolar teeth which are indicated for extraction, where a jumping gap is most likely to form (≥2mm) provides a reliable environment to study the local effects of rhBMP-2 in consistent and replicable conditions. 2\. Apical bone ≥ 3mm from the vertical structure showed in x-rays beyond the apex. 3\. Patients who are willing to comply the study and agree to provide their consent. 4\. Good to fair oral hygiene. Exclusion Criteria: \- 1. Active infection or inflammation in implant area. 2. Medically compromised patients such as uncontrolled diabetes, coagulation disorders, immune compromised patient, patient treated with bisphosphate drugs, psychiatric problems, pregnant women, or any medical condition that affect bone healing. 3\. Clinical evidence of parafunctional habits. 4. Heavy smokers (≥20 cigarettes a day).

Outcomes

Primary Outcomes

Implant Stability Quotient (ISQ) measured by Resonance Frequency Analysis

Evaluation of implant stability using resonance frequency analysis (RFA) device to measure the Implant Stability Quotient (ISQ) at baseline and 16 weeks after implant placement.

Time frame: Baseline and 16 weeks after implant placement

Secondary Outcomes

Marginal Bone Level (MBL) Changes around Dental Implants

Radiographic assessment of marginal bone level (MBL) around dental implants using Cone Beam Computed Tomography (CBCT) at baseline and 16 weeks after implant placement.