Enavogliflozin for the Management of Patients With Amyloid CardiomyopaThy

Inclusion Criteria: 1. Adults aged 19 years or older 2. Diagnosed with amyloid cardiomyopathy confirmed by cardiac biopsy or non-invasive imaging 3. Presence of heart failure symptoms corresponding to NYHA functional class II-III 4. Patients on stable oral diuretic use, without dose changes exceeding 50% of the previous dose, for at least 2 weeks prior to study enrollment 5. Ambulatory (able to walk) 6. Able to provide written informed consent for study participation Exclusion Criteria: 1. Pregnant or breastfeeding women 2. Active infection 3. Major cardiovascular events (e.g., myocardial infarction, stroke) within the past 6 months 4. Scheduled for coronary revascularization, CRT-D implantation, atrial flutter/fibrillation ablation, or valve surgery 5. History of heart transplantation 6. Estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73 m² (calculated by CKD-EPI formula) 7. No history of cancer within the past 5 years at screening (except borderline cancers without recurrence for 2-3 years; multiple myeloma with cardiac involvement is classified as cardiac amyloidosis and is exempt) 8. Heart failure primarily caused by severe left sided valvular disease or ischemic heart disease (except if valvular disease is corrected) 9. Type 1 diabetes mellitus or insulin-dependent diabetes 10. History of ketoacidosis, complicated urinary or genital infections, or kidney stones 11. Systolic blood pressure \< 80 mmHg or symptomatic hypotension 12. Major surgery within 90 days prior to enrollment 13. Known hypersensitivity or allergic reaction to the study drug or its components 14. Moderate to severe liver impairment 15. Chronic alcohol or substance abuse 16. Residing in long-term care facilities (e.g., nursing homes) 17. Unable to understand or comply with study drug, procedures, or follow-up, or who are deemed by the investigator to be unlikely to complete the study