A Community-based Prospective Cohort Study on Metabolic Dysfunction-Associated Fatty Liver Disease in Older Adults: From Metabolic Trajectories to Extrahepatic Outcomes

N/ANot Yet RecruitingNCT07241195

The Affiliated Hospital of Hangzhou Normal University20,000 enrolled

Overview

To establish a cohort of elderly fatty liver disease based on the community medical examination population. Through the large-scale cohort study, the risk factors affecting fatty liver in the elderly will be explored in depth from the aspects of lifestyle, environment and genetics, the development pattern and mechanism of fatty liver in the elderly will be analysed, and the health risk assessment system and Chinese standard for fatty liver in the elderly covering cardiovascular risk, risk of hepatic fibrosis and risk of sarcopenia will be established, so as to provide the scientific basis for the precise intervention of fatty liver in the elderly in China.

Study Type

OBSERVATIONAL

Enrollment

20,000

Conditions

NAFLD and NASH NAFLD( Non-alcoholic Fatty Liver Disease )NAFLD Cirrhosis

Eligibility

Sex: ALLMin age: 65 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ① Elderly people aged ≥65 years among permanent residents (living for more than 5 years) in the survey area; * Imaging diagnosis (ultrasound or FibroScan/FibroTouch) of fatty liver; -③ Voluntary participation in this study and signing an informed consent form. Exclusion Criteria: * ①Major disability, mental illness, major wasting disease, severe cardiac, pulmonary and renal insufficiency; * Patients with combined primary liver cancer or other types of cancer; -③Patients who have received liver transplant or other organ transplants.

Outcomes

Primary Outcomes

Incidence of liver fibrosis

Time frame: 2 years

Secondary Outcomes

Incidence of cardiovascular disease

Time frame: 2 years

Incidence of sarcopenia

Time frame: 2 years

A Community-based Prospective Cohort Study on Metabolic Dysfunction-Associated Fatty Liver Disease in Older Adults: From Metabolic Trajectories to Extrahepatic Outcomes

Overview

Conditions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts