The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD). Participation in the study will last about 5 years.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
7,140
Administered orally
Administered orally
Time to First Occurrence of Composite Endpoint of Major Cardiovascular Events
Composite endpoint includes nonfatal myocardial infarction, nonfatal stroke, hospitalization or urgent visit due to heart failure, coronary revascularization, or all-cause death
Time frame: Baseline up to end of study (about 5 years)
Time to First Occurrence of Composite Endpoint of Major Cardiovascular and Kidney Events
Composite endpoint includes nonfatal myocardial infarction, nonfatal stroke, hospitalization or urgent visit due to heart failure, coronary revascularization, ≥40% sustained decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or all-cause death
Time frame: Baseline up to end of study (about 5 years)
Change from Baseline in Total eGFR Slope
Time frame: Baseline up to end of study (about 5 years)
Time to Onset of Type 2 Diabetes
Time frame: Baseline up to end of study (about 5 years)
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Instituto de Investigaciones Clínicas Bahia Blanca
Bahía Blanca, Argentina
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NOT_YET_RECRUITINGCardiología Palermo
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NOT_YET_RECRUITINGGlenny Corp. S.A.
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NOT_YET_RECRUITING...and 551 more locations