Water-injecting Endoscopic Submucosal Dissection for Early Gastric Cancer: a Retrospective Cohort Study

Shanghai East Hospital548 enrolled

Overview

Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure. Several water-jet knives have been developed to address this issue. The aim of this study was to develop a new ESD method using continuous low-pressure water injection at 1-2 atmosphere with a tip-injected electric knife while dissection simultaneous cutting, dissection, electrocoagulation, and hemostasis, which was so called as water-injecting ESD (W-ESD) to treat early gastric cancer and compare the efficacy and safety with conventional methods.

Study Type

OBSERVATIONAL

Enrollment

548

Conditions

Endoscopic Resection Early Gastric Cancer

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age ≥ 18 years; 2. histologically proven early gastric adenocarcinoma; 3. meeting the absolute or expanded indication for ESD according to the Japanese gastric cancer treatment guidelines 2021 ; 4. Eastern Cooperative Oncology Group performance status ≤ 2; 5. adequate hematological function (hemoglobin ≥ 9 g/dL, platelets ≥ 50 000/mm3，international normalized ratio\<1.5); 6. sufficient renal function (serum creatinine ≤ 2.0 mg/dL); and (7) adequate hepatic function (serum aspartate aminotransferase ≤ 100 IU/L, serum alanine aminotransferase ≤ 100 IU/L). Exclusion Criteria: 1. pregnancy or breastfeeding; 2. difficulty obtaining consent due to psychiatric disorder; 3. multiple lesions; 4. history of gastrectomy or gastrointestinal reconstruction surgery.