Supplementation With Sirtuin Activators in Women With Increased Body Weight

Poznan University of Life Sciences120 enrolled

Overview

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are: Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing? Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status. Participants will: Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

120

Conditions

Obesity & Overweight

Interventions

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * females * age: 40-65 years * overweight or obese: BMI \>25 kg/m2 Exclusion Criteria: * males * BMI \< 25 kg/m2 * sirtuin activators administration for 3 months prior to study * pregnancy or breastfeeding * recent dieting or being on calorie restricted diet * receiving pharmacotherapy to treat obesity, diabetes or hyperlipidemia * post-bariatric surgery * diabetes * cancer * chronic kidney, liver or autoimmune diseases * alcohol addiction

Outcomes

Primary Outcomes

Concentrations of blood lipids

Total cholesterol, Triacyglycerols, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesteroll