Congenital heart diseases (CHDs) are common in infants with cholestasis due to shared prenatal and metabolic factors. This study aims to determine the frequency and types of CHDs and to assess physical and mental development in children below two years with cholestasis at Assiut University Children's Hospital.
Congenital heart diseases (CHDs) are the most common structural malformations in childhood, affecting approximately 8-12 per 1,000 live births worldwide. Infants with systemic disorders such as neonatal and infantile cholestasis have a higher prevalence of CHDs due to overlapping prenatal insults, genetic syndromes, and metabolic disturbances. Cholestasis, defined as impaired bile flow with conjugated hyperbilirubinemia, may arise from biliary atresia, neonatal hepatitis, or metabolic and syndromic disorders such as Alagille syndrome. Several studies highlight a strong association between cholestasis and CHDs, and early recognition of this dual burden is essential to improve outcomes.
Study Type
OBSERVATIONAL
Enrollment
106
Frequency of CHDs among cholestatic infants
Assessment of prevalence of congenital heart diseases in infants below 2 years with cholestasis.
Time frame: At initial clinical evaluation
Types of CHDs identified in cholestatic infants
At baseline echocardiographic assessment
Time frame: During hospital evaluation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.