This trial aims to evaluate the efficacy, safety, and tolerability of fractional laser combined with topical exosome for hair regrowth in patients with androgenetic alopecia. This study is expected to recruit 30 participants. The experimental group will receive fractional laser treatment combined with human umbilical cord mesenchymal stem cell exosome solution; the control group will receive fractional laser treatment combined with a placebo. Participants will receive three fractional laser treatments and will be followed up for 6 months. At each follow-up visit, hair density, diameter, vellus hair to terminal hair ratio, and adverse reactions will be assessed using trichotomy; a global photographic assessment will be performed using standardized imaging equipment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
We will performed the fraction laser on the scalp of participants with energy of 30-40mJ every month for 3 times.
Chang Gung Memorial Hospital Taoyuan branch
Taoyuan, Taoyuan, Taiwan
Change in hair density (d84)
Evaluation of the change in hair density of fractional laser combined with exosomes in improving hair growth
Time frame: Baseline to Day 84
Change in hair density (d168)
Evaluation of the change in hair density of fractional laser combined with exosomes in improving hair growth.
Time frame: Baseline to Day 168
Change in Hair diameter (d168)
Evaluation of the change in hair diameter of fractional laser combined with exosomes in improving hair growth.
Time frame: Baseline to Day 168
Change in the percentage of vellus hair and terminal hair (d168)
Evaluation of the change in the percentage of vellus hair and terminal hair of fractional laser combined with exosomes in improving hair growth
Time frame: Baseline to Day 168
Change in global photographic assessment (d168)
Evaluation of the change in global photographic assessment of fractional laser combined with exosomes in improving hair growth
Time frame: Baseline to Day 168
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