This study aims to determine whether congenital heart disease increases chronic health risks and mortality in childhood hematological tumor survivors, explore potential shared genetic factors between these conditions, identify other factors affecting long-term outcomes and quality of life, and validate any discovered genetic links through mechanistic investigations.
Children with congenital heart disease have a significantly higher risk of developing hematological tumors compared to the general pediatric population, although the clinical characteristics and prognosis of such comorbid cases have previously lacked systematic investigation. The study is set to include children with comorbid congenital heart disease and hematological tumors, comparing them with those without congenital heart disease, to conduct a detailed analysis of their clinical data, treatment responses, and survival outcomes.
Study Type
OBSERVATIONAL
Enrollment
800
Beijing Children's Hospital
Beijing, China
The Third Xiangya Hospital of Central South University
Changsha, China
Occurrence of all-cause death
Time frame: from enrollment to follow-up for 5 year
Frequency and severity of SAEs assessed by CTCAE v5.0
CommonTerminology Criteria for Adverse Events（CTCAE）has 5 levels of AE determination, increasing in severity as the level increases
Time frame: from enrollment to follow-up for 5 year
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